ORAL IMMUNIZATION AGAINST THE PNEUMOCOCCUS

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Oral Immunization against the Pneumococcus

1. Feeding heat killed pneumococci grown in milk produces a fair degree of immunity. 2. Feeding acid killed degraded aruvilent organisms produces little protection. 3. Feeding the desiccated, mechanically disrupted organisms creates a high degree of protection. 4. Feeding the Berkefeld filtrate of sodium glycocholate dissolved cells produce a high degree of immunity. 5. A single ingestion of th...

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The Rôle of the Soluble Specific Substance in Oral Immunization against Pneumococcus Type I

1. Feeding the purified soluble specific substance of Type I pneumococcus protects rats against an intraperitoneal injection of the virulent organism. 2. This increased resistance resembles that obtained when the intact (dead) or dissolved bacteria are fed, as follows: (a) one feeding is sufficient, (b) the interval between the feeding and the appearance of the immunity is the same, (c) the dur...

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The Rôle of the Soluble Specific Substance in Oral Immunization against Pneumococcus Types Ii and Iii

1. When the soluble specific substance of Type II pneumococcus was fed to rats, little or no increased resistance to the organism was obtained. 2. When the specific substance of Type III pneumococcus was fed, an increased resistance to the virulent organism resulted. The percentage of animals protected is smaller than when the whole or the dissolved cell is fed. 3. When the specific polysacchar...

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Oral Immunization against Pneumococcus Types Ii and Iii and the Normal Variation in Resistance to These Types among Rats

1. Considerable variation in the resistance of different rats toward Type II pneumococcus has been demonstrated. In general, older rats survive much greater doses than young ones, illustrating the acquisition of a natural partial immunity. The same is true for Type III but the immunity appears somewhat later in life and does not reach the same height. 2. An active immunity can be created agains...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1930

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.51.4.585